… Abnormal expression or mutation of FEN1 in cells can cause a series of pathological …
autoimmune diseases (systemic lupus erythematosus) and chronic inflammatory responses [68]. …

… due to FEN1 E160D mutation, which may induce autoimmunity that would … of FEN1 gene
mutation on the progression of LN. We first observed that in the association of FEN1 mutations …

… in the nuclease activity of Fen1, which is similar to the mutations identified in human lung
cancers and linked with autoimmunity and chronic inflammation [147]. Whether these …

… of chronic inflammation and cancer [214]. Mutation leading to FEN1 overexpression is a …
TAM signaling components can lead to autoimmunity and a state of chronic inflammation [92,93]…

… In the current work, we report a novel colorectal cancer-associated FEN1 mutation, L209P. …
FEN1 mutant mice are predisposed to autoimmunity, chronic inflammation and cancers. …

… Fen1 exonuclease resulted in cancer initiation and a chronic … in order to induce mutations
driving cancer development. … as cancer, age-related pathologies, autoimmune and chronic …

… Mutations in FEN1 may also be linked to lupus … Therefore, the mutations or neoantigens
that originate from … to cancer but also to the emergence of a specific autoimmune response. …

… Knock-in of a cancer-related inactivating Fen1 mutation resulted in a high … Fen1 mutant
mouse model displayed a marked predisposition to chronic inflammation and autoimmunity (120)…

… , targeting FEN1 could serve as a potent strategy for cancer … that FEN1 is overexpressed in
breast cancers and is essential … The FEN1 E359K germline mutation disrupts the FEN1-WRN …

… FEN1 E160D mutation were predisposed to autoimmunity, chronic inflammation, and cancers,
… Our team identified the FEN1 mutation in colorectal cancer cells and evaluated its function …